I think he was getting at that Geordi’s decision to remain blind and accommodated with his VISOR ended up having unforeseen positive consequences. In other words, pluralism leads to unforeseen positive side effects.

The core theme is that the Federation provides individuals with agency over their bodies. Sure, Geordi’s mother could have had his blindness cured before he would have known anything different, but it’s his body and ultimately his choice. Interestingly, we see the opposite with Dr. Bashir. His genetic enhancements don’t just offend the Federation because of historical trauma with the Eugenics Wars but because his parents didn’t even give him choice in the matter (at least, that’s how I’ve interpreted it).

This right here. I liked how TNG did it. Series premier bring an oldster in to launch, maybe have a special episode or two with another.

If we really wanted Colm back, have it in the premier of Starfleet Academy where the new cadets are going through a hall of distinguished professors and have an elderly O’Brien do a cameo with a sample of one of his lectures. Nice to connect the show to lore and nostalgia but short enough to let the new cast stand on their own.

That said, I agree with Colm. Let O’Brien stay as he is. He had a perfect send-off.