Basically this mutation is shown to protect against malaria, but it causes an issue with producing a molecule needed for the creation of ATP (energy your body needs)

So while they can offer a protective effect to the subject they could need transfusions or other treatment to stay healthy.

Subject 1 & 2 had similar biomarkers, and subject 3 had different markers causing a type of misread that made them transfusion dependent.

That’s my understanding at least

They are actually doing a bit better than we thought

https://www.npr.org/2022/07/23/1113186725/tigers-population-numbers-endangered-species

Yeah I can’t imagine there are a bunch, I remember specifically encountering one commenter saying they were like 13 or something in a post.

So maybe there are dozens of them